pasquale-pagliaro

Biography

Name:

Pasquale Pagliaro

Title:

Professor

Institution:

University of Torino

Email:

[email protected]

Website:

http://www.sirc-cardio.it

Early career investigator (ECI):

No

Short biography of member:

Pasquale Pagliaro, M.D., Ph.D. is full Professor of Physiology at the University of Turin, Italy. He was born in Rossano (CS), Italy, in 1961. He graduated in Medicine in 1988 (11/04/1988). In 1994 he received a doctorate in Cardiovascular Physiology discussing a thesis on the role of nitric oxide in the coronary circulation. From 1996 to 1999 he spent several periods at Johns Hopkins University, first as a researcher, then as a visiting scientist. Prof. Pagliaro has received numerous honors, prizes and awards. He is a member of the following scientific societies: Italian Society of Physiology, Physiological Society (London), Italian Society of Cardiology and Italian Cardiovascular Research Society. Since January 2013 he is President of the Italian Society of Cardiovascular Research. He is vice-chair of the Cardiotoxicity and Cardioprotection working-group of the Italian Society of Cardiology. He is also vice-chair of the PhD program in Experimental Medicine and Therapy of the University of Turin. He has been invited as speaker and/or chairperson in several national and international meetings. He has been invited lecturer at the Summer School of European Society of Cardiology. The main research interests of Prof. Pagliaro are the coronary circulation and the cardioprotective mechanisms for the repair and regeneration of the myocardium. His research laboratory has been funded by various agencies. Professor Pagliaro has published more than 150 peer-reviewed articles. On Scopus, his h-index is 33 with a total citation of 3384 by 2312 documents (January 30, 2018). On Google Scholar, his h-index is 41 with total citations of 5507 (January 30, 2018). Professor Pagliaro translated form the English to Italian the chapters of cardiovascular physiology from two important books, namely the Guyton & Hall Medical Physiology and the Medical Physiology of Ganong.

Country:

IT, Italy

Publications list:

1. Penna C, Sorge M, Femminò S, Pagliaro P, Brancaccio M. Redox Aspects of Chaperones in Cardiac Function. Front Physiol. 2018 Mar 16;9:216. doi: 10.3389/fphys.2018.00216. eCollection 2018. Review. PubMed PMID: 29615920; PubMed Central PMCID: PMC5864891. 2. Varricchi G, Ameri P, Cadeddu C, Ghigo A, Madonna R, Marone G, Mercurio V, Monte I, Novo G, Parrella P, Pirozzi F, Pecoraro A, Spallarossa P, Zito C, Mercuro G, Pagliaro P, Tocchetti CG. Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective. Front Physiol. 2018 Mar 7;9:167. doi: 10.3389/fphys.2018.00167. eCollection 2018. Review. PubMed PMID: 29563880; PubMed Central PMCID: PMC5846016. 3. Folino A, Accomasso L, Giachino C, Montarolo PG, Losano G, Pagliaro P, Rastaldo R. Apelin-induced cardioprotection against ischaemia/reperfusion injury: roles of epidermal growth factor and Src. Acta Physiol (Oxf). 2018 Feb;222(2). doi: 10.1111/apha.12924. Epub 2017 Aug 30. PubMed PMID: 28748611. 4. Penna C, Tullio F, Femminò S, Rocca C, Angelone T, Cerra MC, Gallo MP, Gesmundo I, Fanciulli A, Brizzi MF, Pagliaro P, Alloatti G, Granata R. Obestatin regulates cardiovascular function and promotes cardioprotection through the nitric oxide pathway. J Cell Mol Med. 2017 Dec;21(12):3670-3678. doi: 10.1111/jcmm.13277. 5. Russo I, Penna C, Musso T, Popara J, Alloatti G, Cavalot F, Pagliaro P. Platelets, diabetes and myocardial ischemia/reperfusion injury. Cardiovasc Diabetol. 2017 May 31;16(1):71. doi: 10.1186/s12933-017-0550-6. Review. PubMed PMID: 28569217; PubMed Central PMCID: PMC5452354. 6. Mastrocola R, Aragno M, Alloatti G, Collino M, Penna C, Pagliaro P. Metaflammation: tissue-specific alterations of the NLRP3 inflammasome platform. Curr Med Chem. 2017 Apr 7. doi: 10.2174/0929867324666170407123522. [Epub ahead of print] PubMed PMID: 28403789. 7. Tocchetti CG, Cadeddu C, Di Lisi D, Femminò S, Madonna R, Mele D, Monte I, Novo G, Penna C, Pepe A, Spallarossa P, Varricchi G, Zito C, Pagliaro P*#, Mercuro G*. From Molecular Mechanisms to Clinical Management of Antineoplastic Drug-Induced Cardiovascular Toxicity: A Translational Overview. Antioxid Redox Signal. 2017 May 15. doi: 10.1089/ars.2016.6930. [Epub ahead of print] PubMed PMID: 28398124.*PP and MG share seniorship. # Corresponding author. 8. Tullio F, Penna C, Cabiale K, Femminò S, Galloni M, Pagliaro P. Cardioprotective effects of calcitonin gene-related peptide in isolated rat heart and in H9c2 cells via redox signaling. Biomed Pharmacother. 2017 Jun;90:194-202. doi: 10.1016/j.biopha.2017.03.043. Epub 2017 Mar 29. PubMed PMID: 28364596. 9. Morano M, Angotti C, Tullio F, Gambarotta G, Penna C, Pagliaro P*, Geuna S. Myocardial ischemia/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: role in oxidative stress. Article reference: IJCA24491, Journal: International Journal of Cardiology, 2017 Apr 15;233:73-79. doi: 10.1016/j.ijcard.2017.01.122. *Corresponding author: Pasquale Pagliaro. 10. Angotti C, Venier-Julienne MC, Penna C, Femminò S, Sindji L, Paniagua C, Montero-Menei CN, Pagliaro P. Nanoprecipitated catestatin released from pharmacologically active microcarriers (PAMs) exerts pro-survival effects on MSC. Int J Pharm. 2016 Nov 22. pii: S0378-5173(16)31113-9. doi: 10.1016/j.ijpharm.2016.11.050. 11. Mastrocola R, Penna C, Tullio F, Femminò S, Nigro D, Chiazza F, Serpe L, Collotta D, Alloatti G, Cocco M, Bertinaria M, Pagliaro P, Aragno M, Collino M. Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways. Oxid Med Cell Longev. 2016;2016:5271251. doi: 10.1155/2016/5271251. 12. Maurea N, Spallarossa P, Cadeddu C, Madonna R, Mele D, Monte I, Novo G, Pagliaro P, Pepe A, Tocchetti CG, Zito C, Mercuro G. A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e93-e104. 13. Spallarossa P, Maurea N, Cadeddu C, Madonna R, Mele D, Monte I, Novo G, Pagliaro P, Pepe A, Tocchetti CG, Zito C, Mercuro G. A recommended practical approach to the management of anthracycline-based chemotherapy cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e84-e92. 14. Deidda M, Madonna R, Mango R, Pagliaro P, Bassareo PP, Cugusi L, Romano S, Penco M, Romeo F, Mercuro G. Novel insights in pathophysiology of antiblastic drugs-induced cardiotoxicity and cardioprotection. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e76-e83. 15. Cadeddu C, Mercurio V, Spallarossa P, Nodari S, Triggiani M, Monte I, Piras R, Madonna R, Pagliaro P, Tocchetti CG, Mercuro G. Preventing antiblastic drug-related cardiomyopathy: old and new therapeutic strategies. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e64-e75. PubMed PMID: 27755244. 16. Novo G, Cadeddu C, Sucato V, Pagliaro P, Romano S, Tocchetti CG, Zito C, Longobardo L, Nodari S, Penco M. Role of biomarkers in monitoring antiblastic cardiotoxicity. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e27-e34. 17. Mele D, Tocchetti CG, Pagliaro P, Madonna R, Novo G, Pepe A, Zito C, Maurea N, Spallarossa P. Pathophysiology of anthracycline cardiotoxicity. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e3-e11. 18. Pagliaro P, Penna C. Hypertension, hypertrophy, and reperfusion injury. J Cardiovasc Med (Hagerstown). 2017 Mar;18(3):131-135. doi: 10.2459/JCM.0000000000000435. 19. Mastrocola R, Collino M, Penna C, Nigro D, Chiazza F, Fracasso V, Tullio F, Alloatti G, Pagliaro P, Aragno M. Maladaptive modulations of NLRP3 inflammasome and cardioprotective pathways are involved in diet-induced exacerbation of myocardial ischemia/reperfusion injury in mice. Oxid Med Cell Longev. 2016;2016:3480637. 20. Gallina C, Capelôa T, Saviozzi S, Accomasso L, Catalano F, Tullio F, Martra G, Penna C, Pagliaro P, Turinetto V, Giachino C. Human mesenchymal stem cells labelled with dye-loaded amorphous silica nanoparticles: long-term biosafety, stemness preservation and traceability in the beating heart. J Nanobiotechnology. 2015 Oct 29;13:77. 21. Crisafulli A, Pagliaro P, Cohen-Solal A, Coats AJ. Effects of Physical Exercise on Cardiovascular Diseases: Biochemical, Cellular, and Organ Effects. Biomed Res Int. 2015;2015:853632. 22. Boero M#, Pagliaro P, #, Tullio F, Pellegrino RM, Palmieri A, Ferbo L, Saglio G,De Gobbi M, Penna C, Roetto A. A comparative study of myocardial molecular phenotypes of two tfr2β null mice: role in ischemia/reperfusion. Biofactors. 2015 Sep-Oct;41(5):360-71. #Equal contribution. 23. Pagliaro P A Man Is As Young As His Endothelium. Physiology News. 2015; 99: e6 24. Lapi D, Vagnani S, Sapio D, Mastantuono T, Boscia F, Pignataro G, Penna C, Pagliaro P, Colantuoni A. Effects of bone marrow mesenchymal stem cells (BM-MSCs) on rat pial microvascular remodeling after transient middle cerebral artery occlusion. Front Cell Neurosci. 2015 Aug 25;9:329. 25. Pagliaro P, Penna C. Editorial: Protection, Repair and Regeneration of Achybreaky Heart. Curr Drug Targets. 2015;16(8):778-9. 26. Madonna R, Cadeddu C, Deidda M, Mele D, Monte I, Novo G, Pagliaro P, Pepe A, Spallarossa P, Tocchetti CG, Zito C, Mercuro G. Improving the preclinical models for the study of chemotherapy-induced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardiotoxicity and Cardioprotection. Heart Fail Rev. 2015 Sep;20(5):621-31. 27. Madonna R, Cadeddu C, Deidda M, Giricz Z, Madeddu C, Mele D, Monte I, Novo G, Pagliaro P, Pepe A, Spallarossa P, Tocchetti CG, Varga ZV, Zito C, Geng YJ, Mercuro G, Ferdinandy P. Cardioprotection by gene therapy: A review paper on behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology. Int J Cardiol. 2015 Jul 15;191:203-10. 28. Penna C, Granata R, Tocchetti CG, Gallo MP, Alloatti G, Pagliaro P. Endogenous Cardioprotective Agents: Role in Pre and Postconditioning. Curr Drug Targets. 2015;16(8):843-67. 29. Tocchetti CG, Molinaro M, Angelone T, Lionetti V, Madonna R, Mangiacapra F, Moccia F, Penna C, Sartiani L, Quaini F, Pagliaro P. Nitroso-Redox Balance and Modulation of Basal Myocardial Function: An Update from the Italian Society of Cardiovascular Research (SIRC). Curr Drug Targets. 2015;16(8):895-903. 30. Pagliaro P, Penna C. Redox signalling and cardioprotection: translatability and mechanism. Br J Pharmacol. 2015 Apr;172(8):1974-95. 31. Crisafulli, A., Mancardi, D., Marongiu, E., Rastaldo, R., Penna, C., Pagliaro, P. Preconditioning cardioprotection and exercise performance: a radical point of view (Review). Sport Sciences for Health 2 015, 11(2), 137-151 32. Penna C, Pasqua T, Amelio D, Perrelli MG, Angotti C, Tullio F, Mahata SK, Tota B, Pagliaro P, Cerra MC, Angelone T. Catestatin increases the expression of anti-apoptotic and pro-angiogenetic factors in the post-ischemic hypertrophied heart of SHR. PLoS One. 2014 Aug 6;9(8):e102536. 33. Penna C, Brancaccio M, Tullio F, Rubinetto C, Perrelli MG, Angotti C, Pagliaro P *, Tarone G*. Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia/reperfusion injury. Basic Res Cardiol. 2014 Jul;109(4):418. *Equal contribution 34. Penna C, Angotti C, Pagliaro P. Protein S-nitrosylation in preconditioning and postconditioning. Exp Biol Med (Maywood). 2014 Jun;239(6):647-62. 35. Tullio F, Angotti C, Perrelli MG, Penna C, Pagliaro P. Redox balance and cardioprotection. Basic Res Cardiol. 2013 Nov;108(6):392. 36. Cristallini C, Cibrario Rocchietti E, Accomasso L, Folino A, Gallina C, Muratori L, Pagliaro P, Rastaldo R, Raimondo S, Saviozzi S, Sprio AE, Gagliardi M, Barbani N, Giachino C. The effect of bioartificial constructs that mimic myocardial structure and biomechanical properties on stem cell commitment towards cardiac lineage. Biomaterials. 2014 Jan;35(1):92-104. 37. Penna C, Perrelli MG, Tullio F, Angotti C, Camporeale A, Poli V, Pagliaro P. Diazoxide postconditioning induces mitochondrial protein S-nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE. Basic Res Cardiol. 2013 Sep;108(5):371. 38. Pagliaro P, Gattullo D, Penna C. Nitroglycerine and sodium trioxodinitrate: from the discovery to the preconditioning effect. J Cardiovasc Med (Hagerstown). 2013 Oct;14(10):698-704. 39. Penna C, Settanni F, Tullio F, Trovato L, Pagliaro P, Alloatti G, Ghigo E, Granata R. GH-releasing hormone induces cardioprotection in isolated male rat heart via activation of RISK and SAFE pathways. Endocrinology. 2013 Apr;154(4):1624-35. 40. Penna C, Perrelli MG, Tullio F, Angotti C, Pagliaro P. Acidic infusion in early reperfusion affects the activity of antioxidant enzymes in postischemic isolated rat heart. J Surg Res. 2013 Jul;183(1):111-8. 41. Perrelli MG, Tullio F, Angotti C, Cerra MC, Angelone T, Tota B, Alloatti G, Penna C, Pagliaro P. Catestatin reduces myocardial ischaemia/reperfusion injury: involvement of PI3K/Akt, PKCs, mitochondrial KATP channels and ROS signalling. Pflugers Arch. 2013 Jul;465(7):1031-40. 42. Penna C, Perrelli MG, Karam JP, Angotti C, Muscari C, Montero-Menei CN, Pagliaro P. Pharmacologically active microcarriers influence VEGF-A effects on mesenchymal stem cell survival. J Cell Mol Med. 2013 Jan;17(1):192-204. 43. Mognetti B, La Montagna G, Perrelli MG, Pagliaro P, Penna C. Bone marrow mesenchymal stem cells increase motility of prostate cancer cells via production of stromal cell-derived factor-1α. J Cell Mol Med. 2013 Feb;17(2):287-92. 44. Penna C, Tullio F, Perrelli MG, Mancardi D, Pagliaro P. Cardioprotection against ischemia/reperfusion injury and chromogranin A-derived peptides. Curr Med Chem. 2012;19(24):4074-85. 45. Penna C, Pasqua T, Perrelli MG, Pagliaro P*, Cerra MC, Angelone T. Postconditioning with glucagon like peptide-2 reduces ischemia/reperfusion injury in isolated rat hearts: role of survival kinases and mitochondrial KATP channels. Basic Res Cardiol. 2012 Jul;107(4):272. *Corresponding author 46. Penna C, Perrelli MG, Pagliaro P. Mitochondrial pathways, permeability transition pore, and redox signaling in cardioprotection: therapeutic implications. Antioxid Redox Signal. 2013 Feb 10;18(5):556-99. 47. Rastaldo R, Cappello S, Di Stilo A, Folino A, Losano G, Pagliaro P. A lipophilic nitric oxide donor and a lipophilic antioxidant compound protect rat heart against ischemia-reperfusion injury if given as hybrid molecule but not as a mixture. J Cardiovasc Pharmacol. 2012 Mar;59(3):241-8. 48. Perrelli MG, Pagliaro P*, Penna C. Ischemia/reperfusion injury and cardioprotective mechanisms: Role of mitochondria and reactive oxygen species. World J Cardiol. 2011 Jun 26;3(6):186-200. *Corresponding author 49. Rastaldo R, Cappello S, Folino A, Berta GN, Sprio AE, Losano G, Samaja M, Pagliaro P. Apelin-13 limits infarct size and improves cardiac postischemic mechanical recovery only if given after ischemia. Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2308-15. 50. Tocchetti CG, Stanley BA, Murray CI, Sivakumaran V, Donzelli S, Mancardi D, Pagliaro P, Gao WD, van Eyk J, Kass DA, Wink DA, Paolocci N. Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function. Antioxid Redox Signal. 2011 May 1;14(9):1687-98. 51. Penna C, Tullio F, Perrelli MG, Moro F, Abbadessa G, Piccione F, Carriero V, Racca S, Pagliaro P. Ischemia/reperfusion injury is increased and cardioprotection by a postconditioning protocol is lost as cardiac hypertrophy develops in nandrolone treated rats. Basic Res Cardiol. 2011 May;106(3):409-20. 52. Penna C, Alloatti G, Gallo MP, Cerra MC, Levi R, Tullio F, Bassino E, Dolgetta S, Mahata SK, Tota B, Pagliaro P. Catestatin improves post-ischemic left ventricular function and decreases ischemia/reperfusion injury in heart. Cell Mol Neurobiol. 2010 Nov;30(8):1171-9. 53. Pagliaro P, Penna C. Cardiac postconditioning. Antioxid Redox Signal. 2011 Mar 1;14(5):777-9. 54. Pagliaro P, Moro F, Tullio F, Perrelli MG, Penna C. Cardioprotective pathways during reperfusion: focus on redox signaling and other modalities of cell signaling. Antioxid Redox Signal. 2011 Mar 1;14(5):833-50. 55. Penna C, Perrelli MG, Tullio F, Moro F, Parisella ML, Merlino A, Pagliaro P. Post-ischemic early acidosis in cardiac postconditioning modifies the activity of antioxidant enzymes, reduces nitration, and favors protein S-nitrosylation. Pflugers Arch. 2011 Aug;462(2):219-33. 56. Folino A, Rastaldo R, Cappello S, Chiribiri A, Pagliaro P, Losano G. Activity of endothelial factors on myocardial inotropy. Minerva Cardioangiol. 2011 Feb 1. 57. Penna C, Tullio F, Perrelli MG, Moro F, Abbadessa G, Piccione F, Carriero V, Racca S, Pagliaro P. Ischemia/reperfusion injury is increased and cardioprotection by a postconditioning protocol is lost as cardiac hypertrophy develops in nandrolone treated rats. Basic Res Cardiol. 2011 May;106(3):409-20.