Gélinas R., Mailleux F., Dontaine J., Bultot L., Demeulder B., Ginion A., Daskalopoulos E.P., Esfahani H., Dubois-Deruy E., Lauzier B., Gauthier C., Olson A.K., Bouchard B., Des Rosiers C., Viollet B., Sakamoto K, Balligand J.L., Vanoverschelde J.L., Beauloye C., Horman S. and Bertrand L. AMPK activation couteracts cardiac hypertrophy by reducing O-GlcNAcylation (2018) Nat. Comm., 9, 374

Contino S., Porporato P.E., Bird M., Marinangeli C., Opsomer R., Sonveaux P., Bontemps F., Dewachter I., Octave J.-N., Bertrand L., Stanga S. and Kienlen-Campard P. Presenilin 2-dependent maintenance of mitochondrial oxidative capacity and morphology (2017) Front. Physiol., 8, 796

Thomas A., Belaidi E., Moulin S., Horman S., van der Zon G.C., Viollet B., Levy P., Bertrand L., Pepin J.-L., Godin-Ribuot D. and Guigas B. Chronic intermittent hypoxia impairs insulin sensitivity but improves whole-body glucose tolerance by activating skeletal muscle AMPK (2017) Diabetes, 66, 2942-2951

Renguet E., Ginion A., Gélinas R., Bultot L., Auquier J., Robillard Frayne I., Daneault C., Vanoverschelde J.-L., Des Rosiers C., Hue L., Horman S., Beauloye C. and Bertrand L. Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake (2017) Am. J. Physiol. Heart Circ. Physiol., 313, H432-H445.

Van Steenbergen A., Balteau M., Ginion A., Ferté L., Battault S., Ravenstein C.M., Balligand J.L., Daskalopoulos E.P., Gilon P., Despa F., Despa S., Vanoverschelde J.L., Horman S., Koepsell H., Berry G., Hue L., Bertrand L. and Beauloye C. Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart (2017) Sci. Rep., 7:41166.

Mailleux F., Gélinas R., Beauloye C., Horman S. and Bertrand L. O-GlcNAcylation, enemy or ally during cardiac hypertrophy development? (2016) Biochim. Biophys. Acta, 1862, 2232-2243.

Diman A., Boros J., Poulain F., Rodriguez J., Purnelle M., Episkopou H., Bertrand L., Francaux M., Deldicque L. and Decottignies A. Nuclear Respiratory Factor 1 and endurance exercise promote human telomere transcription (2016) Sciences Advances, 2(7), e1600031.

Gommaar D'Hulst G., Ferri A., Naslain D., Bertrand L., Horman S., Francaux M., Bishop D.J. and Deldicque L. Fifteen days of 3,200 m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle (2016) Hypoxia, 4, 1-14.

Craps J., Joris V., De Jongh B., Sonveaux P., Horman S., Lengelé B., Bertrand L., Many M.C., Colin I.M. and Gérard A.C. Involvement of mTOR and regulation by AMPK in early iodine deficiency-induced thyroid microvascular activation (2016) Endocrinology, 157, 2545-2559.

Daskalopoulos E.P., Dufeys C., Bertrand L., Beauloye C. and Horman S. AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation (2016) J. Mol. Cell. Cardiol., 91, 188-200.

Van Caenegem O., Beauloye C., Bertrand L., Horman S., Lepropre S., Sparavier G., Vercruysse J., Bethuyne N., Poncelet A.J., Gianello P., Demuylder P., Legrand E., Beaurin G., Bontemps F., Jacquet L.M. and Vanoverschelde J.L. Hypothermic continuous machine perfusion enables preservation of energy charge and functional recovery of heart grafts in an ex vivo model of donation following circulatory death (2016) Eur. J. Cardiothorac. Surg., 49, 1348-1353.

Beauloye C., Horman S. and Bertrand L. Even is better than odd: One fat may conceal another (2015) Am. J. Physiol. Heart Circ. Physiol., 309, H1112-H1114.

Van Caenegem O., Beauloye C., Vercruysse J., Horman S., Bertrand L., Bethuyne N., Poncelet A.J., Gianello P., Demuylder P., Legrand E., Beaurin G., Bontemps F., Jacquet L.M. and Vanoverschelde J.L. Hypothermic continuous machine perfusion improves metabolic preservation and functional recovery in heart grafts (2015) Transpl. Int., 28, 224-231.

Foretz M., Guigas B., Bertrand L., Pollak M. and Viollet B. Metformin: from mechanism of action to therapies (2014) Cell Metab., 20, 953-966.

Balteau M., Van Steenbergen A., Timmermans A.D., Dessy C., Behets-Wydemans G., Tajeddine N., Castanares-Zapatero D., Gilon P., Vanoverschelde J.L., Horman S., Hue L., Bertrand L. and Beauloye C. AMPK activation by Glucagon-like peptide 1 counteracts the hyperglycemia-induced NADPH oxidase activation in adult cardiomyocytes (2014) Am. J. Physiol. Heart Circ. Physiol., 307, H1120-1133.

Noppe G., Dufeys C., Buchlin P., Marquet N., Castanares-Zapatero D., Balteau M., Hermida N., Bouzin C., Esfahani H., Viollet B., Bertrand L., Balligand J.L., Vanoverschelde J.L., Beauloye C . and Horman S. Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKα1 (2014) J. Mol. Cell. Cardiol., 74, 32–43.

Timmermans A.D., Balteau M., Gélinas R., Renguet E., Ginion A., de Meester C., Sakamoto K., Balligand J.L., Bontemps F., Vanoverschelde J.L., Horman S., Beauloye C. and Bertrand L. A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake (2014) Am. J. Physiol. Heart Circ. Physiol., 306, H1619-1630.

Onselaer M.B., Oury C., Hunter R.W., Eeckhoudt S., Barile N., Lecut C., Morel N., Viollet B., Jacquet L.M., Bertrand L., Sakamoto K., Vanoverschelde J.L., Beauloye C. and Horman S. CAMKKβ/AMPK-α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets (2014) J. Thromb. Haemost., 12, 973-986.

Glorieux C., Auquier J., Dejeans N., Sid B., Demoulin J.B., Bertrand L., Verrax J. and Calderon P.B. Catalase expression in MCF-7 breast cancer cells is mainly controlled by PI3K/Akt/mTor signaling pathway (2014) Biochem. Pharmacol., 89, 217-223.

Belge C., Hammond J., Dubois-Deruy E., Manoury B., Hamelet J., Beauloye C., Markl A., Pouleur A.C., Bertrand L., Esfahani H., Jnaoui K., Götz K.R., Nikolaev V.O., Vanderper A., Herijgers P., Lobysheva I., Iaccarino G., Hilfiker-Kleiner D., Tavernier G., Langin D., Dessy C. and Balligand J.L. Enhanced Expression of 3-Adrenoceptors in Cardiac Myocytes Attenuates Neurohormone-Induced Hypertrophic Remodeling through Nitric Oxide Synthase (2014) Circulation, 129, 451-462.

Ducommun S., Ford R.J., Bultot L., Deak M., Bertrand L., Kemp B.E., Steinberg G.R. and Sakamoto K. Enhanced activation of cellular AMPK by dual small molecule treatment: AICAR and A769662 (2014) Am. J. Physiol. Endocrinol. Metab., 306, E688-E696.

de Meester C., Timmermans A.D., Balteau M., Ginion A., Roelants V., Noppe G., Porporato P.E., Sonveaux P., Viollet B., Sakamoto K., Feron O., Horman S., Vanoverschelde J.L., Beauloye C. and Bertrand L. Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells (2014) Cardiovasc. Res.,101, 20-29.

Seront E., Pinto A., Bouzin C., Bertrand L., Machiels J.P. and Feron O. PTEN deficiency is associated with reduced sensitivity to mTOR inhibitor in human bladder cancer through the unhampered feedback loop driving PI3K/Akt activation (2013) Br. J. Cancer, 109, 1586-92.

Castanares-Zapatero D., Bouleti C., Sommereyns C., Gerber B., Lecut C., Mathivet T., Horckmans M., Communi D., Foretz M., Vanoverschelde J.L., Germain S., Bertrand L., Laterre P.F., Oury C., Viollet B., Horman S. and Beauloye C. Connection Between Cardiac Vascular Permeability, Myocardial Edema, and Inflammation During Sepsis: Role of the α1AMP-Activated Protein Kinase Isoform (2013) Crit. Care Med., 41, e411-e422.

Audouard E., Schakman O., Ginion A., Bertrand L., Gailly P. and Clotman F. The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development (2013) Mol. Cell. Neurosci., 56C, 159-168.

Demeulder B., Zarrinpashneh E., Ginion A., Viollet B., Hue L., Rider M.H., Vanoverschelde JL., Beauloye C., Horman S. and Bertrand L. Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart (2013) Biochim. Biophys. Acta., 1832, 780-790.

Steinbusch L.K., Dirkx E., Hoebers N.T., Roelants V., Foretz M., Viollet B., Diamant M., van Eys G., Ouwens D.M., Bertrand L., Glatz J.F. and Luiken J.J. Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes (2013) J. Mol. Cell. Cardiol., 55, 165-173.

Horman S., Beauloye C., Vanoverschelde J.L. and Bertrand L. AMP-activated protein kinase in the control of cardiac metabolism and remodeling (2012) Curr. Heart Fail. Rep., 9, 164-173.

Prévot P.P., Simion A., Grimont A., Colletti M., Khalaileh A., Van den Steen G., Sempoux C., Xu X., Roelants V., Hald J., Bertrand L., Heimberg H., Konieczny S.F., Dor Y., Lemaigre F.P. and Jacquemin P. Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia (2012) Gut, 61, 1723-1732.

Gruson D., Ginion A., Lause P., Ketelslegers J.M., Thissen J.P. and Bertrand L. Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes (2012) Peptides, 33, 351-353.

Gruson D., Ginion A., Decroly N., Lause P., Vanoverschelde J.L., Ketelslegers J.M., Bertrand L. and Thissen J.P. Urocortin-induced cardiomyocytes hypertrophy is associated with regulation of the GSK-3b pathway (2012) Heart Vessels, 27, 202-207.

Kalista S., Schakman O., Gilson H., Lause P., Demeulder B., Bertrand L., Pende M. and Thissen J.P. The type 1 insulin-like growth factor receptor (IGF-IR) pathway is mandatory for the follistatin-induced skeletal muscle hypertrophy (2012) Endocrinology, 153, 241-253.

Beauloye C., Bertrand L., Horman S. and Hue L. AMPK, a potential therapeutic target against the transition from cardiac injury to heart failure (2011) Cardiovasc. Res., 90, 224-233.

Balteau M., Tajeddine N., de Meester C., Ginion A., Des Rosiers C., Brady N., Horman S., Vanovershelde JL., Gailly P., Hue L., Bertrand L. and Beauloye C. NADPH oxidase activation by hyperglycemia in cardiomyocytes is independent of glucose metabolism but requires SGLT-1 (2011) Cardiovasc. Res., 92, 237-246.

Poncelet A.J., van Steenberghe M., Moniotte S., Detaille T., Beauloye C., Bertrand L., Nassogne M.C. and Rubay J.E. Cardiac and neurological assessment of normothermia/warm blood cardioplegia vs hypothermia/cold crystalloid cardioplegia in pediatric cardiac surgery: insight from a prospective randomized trial (2011) Eur. J. Cardiothorac. Surg., 40, 1384-1390.

Deldicque L., Bertrand L., Patton A., Francaux M. and Baar K. ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1 (2011) PLoS One, 6, e20993.

Ginion A., Auquier J., Benton CR., Mouton C., Vanoverschelde JL., Hue L., Horman S., Beauloye C. and Bertrand L. Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake (2011) Am. J. Physiol. Heart Circ. Physiol., 301, H469-H477.

Mouton V., Toussaint L., Vertommen D., Gueuning MA., Maisin L., Havaux X., Sanchez-Canedo C., Bertrand L., Dequiedt F., Hemmings BA., Hue L. and Rider MH. Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3) (2010) Biochem. J., 431, 267-275.

Gruson D., Ginion A., Decroly N., Lause P., Vanoverschelde JL., Ketelslegers JM., Bertrand L. and Thissen JP. Urotensin II induction of adult cardiomyocytes hypertrophy involves the Akt/GSK-3β signaling pathway (2010) Peptides, 31, 1326-1333.

Sanchez Canedo C., Demeulder B., Ginion A., Bayascas JR., Balligand JL., Alessi DR., Vanoverschelde JL., Beauloye C., Hue L. and Bertrand L. Activation of the cardiac mTOR/p70S6K pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation (2010) Am. J. Physiol. Endocrinol. Metab., 298, E761-E769.

Viollet B, Athea Y., Mounier R., Guigas B., Zarrinpashneh E., Horman S., Devin-Leclerc J., Beauloye C., Foretz M., Andreelli F., Ventura-Clapier R. and Bertrand L. AMPK : Lessons from animal models (2009) Front. Biosci., 14, 19-44.

Nath N., Khan M., Rattan R., Magalam A., Makker RS., de Meester C., Bertrand L., Chen Y., Viollet B. and Giri S. Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity (2009) Biochem. Biophys. Res. Com., 386, 16-20.

Habets DDJ., Coumans WA., El Hasnaoui M., Zarrinpashneh E, Bertrand L., Viollet B., Kiens B., Jensen TE., Richter EA., Bonen A., Glatz JFC. and Luiken JJFP. Crucial role for LKB1 to AMPKα2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes (2009) Biochim. Biophys. Acta., 1791, 212-219.

Vancraeynest D., Havaux X., Pasquet A., Gerber B., Beauloye C., Rafter P., Bertrand L. and Vanoverschelde JL. Myocardial injury induced by ultrasound-targeted microbubble destruction: Evidence for the contribution of myocardial ischemia (2009) Ultrasound Med. Biol., 35, 672-679.

Toussaint L., Cuypers M.G., Bertrand L., Hue L., Romão C.V., Saraiva L.M., Teixeira M., Meyer-Klaucke W., Feiters M.C. and Crichton R.R. Comparative Fe and Zn K-edge X-ray absorption spectroscopic study of the ferroxidase centres of human H-chain ferritin and bacterioferritin from Desulfovibrio desulfuricans (2009) J. Biol. Inorg. Chem., 14, 35-49.

Bertrand L., Horman S., Beauloye C. and Vanoverschelde J.L. Insulin signalling in the heart (2008) Cardiovasc. Res., 79, 238-248.

Roelants V., Labar D., de Meester C., Havaux X., Tabilio A., Gambhir S.S., Di Ianni M., Bol A., Bertrand L. and Vanoverschelde J.L. Comparison between Adenoviral and Retroviral Vectors for the Transduction of the Thymidine Kinase PET Reporter Gene in Rat Mesenchymal Stem Cells (2008) J. Nucl. Med., 49, 1836-1844.

Zarrinpashneh E., Beauloye C., Ginion A., Pouleur A.C., Havaux X., Hue L., Viollet B., Vanoverschelde J.L. and Bertrand L. AMPK2 counteracts the development of cardiac hypertrophy induced by isoproterenol (2008) Biochem. Biophys. Res. Com., 376, 677-681.

Schakman O., Kalista S., Bertrand L., Lause P., Verniers J., Ketelslegers J.M. and Thissen J.P. Role of Akt/GSK-3β/β-catenin transduction pathway in the muscle antiatrophy action of Insulin-like growth factor (IGF)-I in glucocorticoidtreated rats (2008) Endocrinology, 149, 3900-3908.

Deldicque L., Sanchez Canedo C., Horman S., De Potter I., Bertrand L., Hue L. and Francaux M. Antagonistic effects of leucine and glutamine on the mTOR pathway in myogenic C2C12 cells (2008) Amino Acids, 35, 147-155.

Jacquet S., Zarrinpashneh E., Chavey A., Ginion A., Leclerc I., Viollet B., Rutter G.A., Bertrand L. and Marber M.S. The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia (2007) Cardiovasc. Res., 76, 465-472.

Deldique L., Theisen D., Bertrand L., Hespel P., Hue L. and Francaux M. Creatine enhances differenciation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways (2007) Am. J. Physiol. Cell Physiol., 293, C1263-C1271.

Carvajal K., Zarrinpashneh E., Szarszoi O., Joubert F., Athea Y., Mateo P., Gillet B., Vaulont S., Viollet B., Bigard X., Bertrand L., Ventura-clapier R. and Hoerter J. Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion (2007) Am. J. Physiol. Heart Circ. Physiol., 292, H3136-H3147.

Toussaint L., Bertrand L., Hue L., Crichton R.R. and Declercq JP. High resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal binding sites (2007) J. Mol. Biol., 365, 440-452.

Dehoux M., Gobier C., Lause P., Bertrand L., Ketelslegers J.-M. and Thissen J.-P. Inhibition of Atrogin-1 by IGF-I through the Akt/Foxo/GSK3 pathway does not prevent myotube atrophy caused by proinflammatory cytokines (2007) Am. J. Physiol. Endocrinol. Metab., 292, E145-E150.

Mouton V., Vertommen D., Bertrand L., Hue L. and Rider M.H. Evaluation of the role of protein kinace Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation (2007) Cell. Signal., 19, 52-61.

Foretz M., Taleux N., Guigas B., Horman S., Beauloye C., Andreelli F., Bertrand L. and Viollet B. Regulation of energy metabolism by AMPK : a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases (2006) Med. Sci. (Paris), 22, 381-388.

Viollet B., Foretz M., Guigas B., Horman S., Dentin R., Bertrand L., Hue L. and Andreelli F. Activation of AMP-activated protein kinase in the liver : a new strategy for the management of metabolic hepatic disorders (2006) J. Physiol., 574, 41-53.

Zarrinpashneh E., Carjaval K., Beauloye C., Ginion A., Mateo P., Pouleur A.C., Horman S., Vaulont S., Hoerter J., Viollet B., Hue L., Vanoverschelde J.L. and Bertrand L. Role of the alpha2 isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia (2006) Am. J. Physiol. Heart Circ. Physiol, 291, H2875-H2883.

Carette N., Hagen W., Bertrand L., de Val N., Vertommen D., Roland F., Hue L. and Crichton R.R. Optical and EPR spectroscopic studies of demetallation of hemin by L-chain apoferritin (2006) J. Inorg. Biochem., 100, 1426-1435.

Bertrand L., Ginion A., Beauloye C., Hebert A.D., Guigas B., Hue L. and Vanoverschelde J.L. AMP-activated protein kinase activation restores the stimulation of glucose uptake in insulin-resistant cardiomyocytes via the activation of protein kinase B (2006) Am. J. Physiol. Heart Circ. Physiol., 291, 239-250.

Guigas B., Bertrand L., Taleux N., Foretz M., Wiernsperger N., Vertommen D., Andreelli F., Viollet B. and Hue L. 5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation (2006) Diabetes, 55, 865-874.

Depre C., Wang L., Sui Z., Qiu H., Hong C., Hedhli N., Ginion A., Shah A., Pelat M., Bertrand L., Wagner T., Gaussin V. and Vatner S.F. H11 kinase prevents myocardial infarction by preemptive preconditioning of the heart (2006) Circ. Res., 98, 280-288.

Smal C., Vertommen D., Bertrand L., Ntamashimikiro S., Rider M.H., Van Den Neste E. and Bontemps F. Identification of in vivo phosphorylation sites on human deoxycytidine kinase: Role of SER74 in the control of enzyme activity (2006) J. Biol. Chem., 281, 4887-1893.

Sakamoto K., Zarrinpashneh E., Budas G.R., Pouleur A.C., Dutta A., Prescott A.R., Vanoverschelde J.L., Ashworth A., Jovanovic A., Alessi D.R. and Bertrand L. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1 (2006) Am. J. Physiol. Endocrinol. Metab., 290, E780-E788.

Vancraeynest D., Havaux X., Pouleur A.C., Pasquet A., Gerber B., Beauloye C.,Rafter P., Bertrand L. and Vanoverschelde J.L. Myocardial Delivery of Colloidal Nanoparticles using Ultrasound-targeted Microbubble Destruction (2006) Eur. Heart J., 27, 237-245.

Chevalier N., Bertrand L., Rider M.H., Opperdoes F.R., Rigden D.J. and Michels P.A.M. 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae : Molecular characterization, database searches, modelling studies and evolutionary (2005) FEBS J., 272, 3542-3560.

Rider M.H., Bertrand L., Vertommen D., Michels P, Rousseau G.G. and Hue L. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase : head to head with a bifunctional enzyme that controls glycolysis (2004) Biochem. J., 381, 561-579.

Smal C., Cardoen S., Bertrand L., Delacauw A., Ferrant A. Van Den Berghe G., Van Den Este E. and Bontemps F. Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells (2004) Biochem. Pharmacol., 68, 95-103.

Hue L., Beauloye C., Bertrand L., Horman S., Krause U., Marsin A.S., Meisse D., Vertommen D. and Rider M.H. New targets of AMP-activated protein kinase (2003) Biochem. Soc. Trans., 31, 213-215.

Mora A., Davies A.M., Bertrand L., Sharif I., Budas G.R., Jovanovic S., Mouton V., Kahn C.R., Lucocq J.M., Gray G.A., Jovanovic A. and Alessi D.R. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia (2003) EMBO J., 22, 4666-4676.

Hue L., Beauloye C., Marsin A.S., Bertrand L., Horman S. and Rider M.H. Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways (2002) J. Mol. Cell. Cardiol., 34, 1091-1097.

Beauloye C., Marsin A.S., Bertrand L., Vanoverschelde J.L. , Rider M.H. and Hue L. The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism (2002) FEBS lett., 531, 324-328.

Horman S., Browne G.J., Krause U., Patel J.V., Vertommen D., Bertrand L., Lavoine A., Hue L., Proud C.G. and Rider M.H. Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis (2002) Curr. Biol., 12, 1419-1423.

Krause U., Bertrand L. and Hue L. Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes (2002) Eur. J. Biochem., 269, 3751-3759.

Krause U., Bertrand L., Maisin L., Rosa M. and Hue L. Signalling pathway and combinatory effects of insulin and amino acids in isolated rat hepatocytes (2002) Eur. J. Biochem., 269, 3742-3750.

Marsin A.S., Bouzin C., Bertrand L. and Hue L. The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase (2002) J. Biol. Chem., 277, 30778-30783.

Beauloye C., Marsin A.S., Bertrand L., Krause U., Hardie D.G., Vanoverschelde J.L. and Hue L. Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat heart, without affecting total adenine nucleotides (2001) FEBS lett., 505, 348-352.

Beauloye C., Bertrand L., Krause U., Marsin A.S., Dresselears T., Vanstapel F., Vanoverschelde J.L. and Hue L. No-flow ischemia inhibits insulin signaling in heart by decreasing intracellular pH (2001) Circ. Res., 88, 513-519.

Marsin A.S., Bertrand L., Rider M.H., Deprez J., Beauloye C., Vincent M.F., Van den Berghe G., Carling D. and Hue L. Phosphorylation and activation of PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia (2000) Curr. Biol., 10, 1247-1255.

Deprez J., Bertrand L., Alessi D.R., Krause U., Hue L. and Rider M.H. Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase (2000) Biochem. J., 347, 305-312.

Bertrand L., Alessi D.R., Deprez J., Deak M., Viaene E., Rider M.H. and Hue L. Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B (1999) J. Biol. Chem., 274, 30927-30933.

Bertrand L., Vertommen D., Freeman P.M., Wouters J., Depiereux E., Di Pietro A., Hue L. and Rider M.H. Mutagenesis of the fructose 6-phosphate binding site in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (1998) Eur. J. Biochem., 254, 490-496.

Bertrand L., Deprez J., Vertommen D., Di Pietro A., Hue L. and Rider M.H. Site-directed mutagenesis of Lys-174, Asp-179 and Asp-191 in the 2-kinase domaine of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (1997) Biochem. J., 321, 623-627.

Bertrand L., Vertommen D., Depiereux E., Hue L, Rider M.H. and Feytmans E. Modelling of the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase on adenylate kinase (1997) Biochem. J., 321, 615-621.

Bertrand L., Vertommen D., Feytmans E., Di Pietro A., Rider M.H. and Hue L. Mutagenesis of charged residues in a conserved sequence in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (1997) Biochem. J., 321, 609-614.

Vertommen D., Bertrand L., Sontag B., Di Pietro A., Louckx M., Vidal H., Hue L. and Rider M.H. ATP-binding site in the 2-kinase domain of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase : study of the role of Lys-54 and Thr-55 by site-directed mutagenesis (1996) J. Biol. Chem., 271, 17875-17880.

Rider M.H., Crepin K.M., De Cloedt M., Bertrand L.,Vertommen D. and Hue L. Study of the role of Arg-104 and Arg-225 in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase studied by site-directed mutagenesis (1995) Biochem. J., 309, 341-346.

Rider M.H., Crepin K.M., De Cloedt M., Bertrand L. and Hue L. Site-directed mutagenesis of rat muscle 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase : role of Asp-130 in the 2-kinase domain (1994) Biochem. J., 300, 111-115.