attila-kiss

Biography

Name:

Attila.Kiss

Title:

PhD

Institution:

Center for Biomedical Research, Medical University of Vienna, Austria

Email:

[email protected]

Website:

https://www.meduniwien.ac.at/hp/dbf/

Early career investigator (ECI):

Yes

Short biography of member:

Past Position: 2011- 2015 Post doctorial fellow - Karolinska University Hospital, Karolinska Institute, Department of Medicine, Division of Cardiology, Stockholm, Sweden Current Position: 2015 May - Post doc Research associate – Department of Biomedical Research, Medical University of Vienna, Vienna, Austria Education: 2002-2007 University of Szeged, Faculty of Science, Szeged, Hungary - majoring in biology Qualification: 2007 Biologist Post gradual studies: 2007-2011 Albert Szent-Györgyi Medical University, Department of Pharmacology and Pharmacotherapy 2011 University Doctor Degree (PhD) “Summa cum laude” Scientific degrees: Ph.D. Theoretical Medical Science (2011) Title: The antiarrhythmic effect of exogenous peroxynitrite and preconditioning: the involvement of nitric oxide, superoxide and peroxynitrite. http://doktori.bibl.u-szeged.hu/868/ Research experience: In vivo: acute ischemia/reperfusion model of dog, pig and rat. Electrical stimulation of vagus nerve (rat, pig), diabetic model on rat and mice. Myocardial infarction model on rats and mice. Isolated working heart model. In vitro: Protein expression assay (Western blot), fluorescent staining, nitrate/nitrite assay, arginase activity, ELISA and histology. Assessment of vascular function in vitro (wire myograph). Basic knowledge of cell culture. FELASA C certification (ID:1058) Research interest: Cardiovascular physiology, pathophysiology and pharmacology; experimental models of myocardial ischemia/reperfusion and infarction, cardiac arrhythmias, testing of newly developed antiischemic compounds. Focus on the endogenous adaptation of the heart against ischemic and reperfusion injury (e.g remote conditioning). Cardioprotective mechanisms relate to nitric oxide signaling pathway. The adverse role of arginase upregulation in heart and in vascular system following ischemia/reperfusion and heart failure. The protective effect of vagal nerve stimulation on diseased heart and the possible cardioprotecvtive mechanism of non-neuronal cholinergic system. Metabolic syndrome in vasculature and in myocardium. The mechanism of left ventricle remodeling and heart failure, neuregulin-1 mediates vascular- and cardioprotection. The importance of altered microRNAs expression and signaling pathways in the development of myocardial ischemia/reperfusion injury and adverse left ventricle remodeling. Novel approaches for optimizing cardioprotection in cardiac surgery. The pathophysiological role of Tenascin C in cardiovascular disorders. Awards: 2005 Talent students of Scholarship of Jász-Nagykun Szolnok county 2006 Scholarship of Szeged Town 2006 Scholarship of Hungarian Republic 2007 National Students` Scientific Congress, First prize (biology) 2008 Scholarsip of Albert Szent-Györgyi Univerity of Szeged 2008 Best Publication Award of Young Scientist at Depertmant of Pharmacolgy and Pharmacotherapy Institute 2010 Poster award (I. prize) VI. International symposium on myocardial cytprotection 2014 Poster award (I. Prize) Cardiovascular Research Retreat Meeting – Karolinska Institutet, Stockholm, Sweden 2017 Best Basic Science Abstract – 25. Annual Meeting of the Alpe Adria Association of Cardiology, Budapest, Hungary

Country:

AT, Austria

Publications list:

1) Kiss, L. Juhasz, I. Huliák, Á. Végh (2008) Peroxynitrite reduces ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs without involving mitoKATP channels. British Journal of Pharmacology 155: 1015-1024 2) A. Kiss, L. Juhász, K. Kupai, Gy. Seprényi, J. Kaszaki, Á. Végh (2010). The role of nitric oxide, superoxide and peroxynitrite in the antiarrhytmic effects of preconditioning and exogenous peroxynitrite. British Journal of Pharmacology 160: 1263-1272 3) L. Juhász, A. Kiss, E. Nyeső, M. Kovács, Gy. Seprényi, J. Kaszaki, Á. Végh (2011). Is there a trigger role of peroxynitrite in the anti-arrhythmic effect of ischaemic preconditioning and peroxynitrite infusion? European Journal of Pharmacology 667: 306-13 4) Grönros J, Kiss A, Palmér M, Jung C, Berkowitz D, Pernow J (2013). Arginase inhibition improves coronary microvascular function and reduces infarct size following ischemia-reperfusion in a rat model. Acta Physiol (Oxf). 2013 Jun;208(2):172-9 5) Y Tratsiakovich, AT Gonon, A Kiss, J Yang, F Böhm, P Tornvall, M Settergren, K M Channon, PO Sjöquist and J Pernow (2013). Myocardial protection by co-administration of L-arginine and tetrahydrobiopterin during ischemia and reperfusion. Int J of Cardiogy; 169(1):83-8.) 6) Kiss A, Tratsiakovich Y, Gonon AT, Fedotovskaya O, Lanner JT, Andersson DC, Yang J, Pernow J (2014). The role of arginase and rho kinase in cardioprotection from remote ischemic perconditioning in non-diabetic and diabetic rat in vivo. Plos One.; 9(8):e104731. 7) L Juhasz, Sz Deri, G Kisvari, A Kiss, Gy Seprenyi, J Gardi, A Vegh (2014).The effect of ischemic preconditioning on nitric oxide synthase activity during myocardial ischemia and reperfusion in anesthetized dogs. Curr Res Cardiol Vol 1 No 2; 73-78 8) Kovács M, Kiss A, Gönczi M, Miskolczi G, Seprényi G, Kaszaki J, Kohr MJ, Murphy E, Végh Á (2015). Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved? Plos One. 10(4):e0122243. 9) Pernow J, Kiss A, Tratsiakovich Y, Climent B (2015). Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus. British Journal of Pharmacology, 172(19):4684-98. 10) Haller PM, Kiss A, Wojta J, Podesser BK, Huber K (2016). Cardioprotection via the arm? How a blood pressure cuff decreases infarct size. Herz. Epub ahead of print 11) Tratsiakovich Y, Kiss A, Gonon AT, Yang J, Sjöquist PO, Pernow J (2017). Inhibition of Rho kinase protects from ischaemia-reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes. Diab Vasc Dis Res. 14(3):236-245. 12) Kiss A, Tratsiakovich Y, Mahdi A, Yang J, Gonon AT, Podesser BK, Pernow J (2017). Vagal nerve stimulation reduces infarct size via a mechanism involving the alpha-7 nicotinic acetylcholine receptor and down-regulation of cardiac and vascular arginase. Acta Physiol (Oxf). [Epub ahead of print]. 13) Kiss A and Podesser BK (2017). Vagal nerve stimulation protects the heart against myocardial ischemia-reperfusion injury. Argentine Journal of Cardiology. Invited Editorial, Vol 85, No 1, p 4-6. 14) Leiss H, Salzberger W, Jacobs B, Gessl I, Kozakowski N, Blüml S, Puchner A, Kiss A, Podesser BK, Smolen JS, Stummvoll GH. (2017). MicroRNA 155-deficiency leads to decreased autoantibody levels and reduced severity of nephritis and pneumonitis in pristane-induced lupus. PLoS One. 12(7):e0181015. 15) Wernly B, Gonçalves I, Kiss A, Paar V, Mösenlechner T, Leisch M, Santer D, Motloch L, Klein KU, Tretter EV, Kretzschmar D, Podesser B, Jung C, Hoppe UC, Lichtenauer M. Differences in stem cell processing lead to distinct secretomes secretion — implications for differential results of previous clinical trials of stem cell therapy for myocardial infarction. Biotechnol J. 2017 Jul 21. doi: 10.1002/biot.201600732. [Epub ahead of print]. 16) C Schreiber, MS Eilenberg, A Kiss, H Bergmeister, BK Podesser, J Mascherbauer, D Bonderman (2017). Preserved Right Ventricular Integrity in a New Telemetric Rat Model of Severe Pulmonary. Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00278.2017. [Epub ahead of print]. 17) H Qi, L Soto-Gonzalez, KA. Krychtiuk, S Ruhittel, C Kaun, W Speidl, A Kiss, B Podesser, S Yao, K Markstaller, KU Klein, V Tretter. Argon Preconditioning Protects Human Adult Cardiac Myocytes from Oxygen Glucose Deprivation Induced Cell Death by Activation of Extracellular Regulated Kinase (ERK), c-jun N-terminal Kinase (JNK) and Akt (2017). Shock, 2017 [Epub ahead of print]. 18) A. Kiss and B K Podesser. Low-dose of relaxin protect against arrhythmias and adverse left ventricle remodelling (2018). International Journal of Cardiology, 2018, 1: 250: 60-61. 19) B Podesser, M Kreibeich, E Dzilic, D Santer, L Förster, S Ttrojanek, D Abraham, M Krssak, KU Klein, EV Tretter, C Kaun, , J Wojta, B Kapeller, , I F Gonsalves, K Treschert, A Kiss Tenascin-C Promotes Chronic Pressure Overload-induced Cardiac Dysfunction, Hypertrophy and Myocardial Fibrosis. Journal of Hypertension 2017. 20) Attila Kiss, Huaqing Shu, Ouafa Hamza, David Santer, Eva Verena Tretter, Shanglong Yao, Klaus Markstaller, Seth Hallström , Bruno K Podesser, Klaus Klein. Argon preconditioning enhances post-ischemic cardiac functional recovery following cardioplegic arrest and global cold ischemia (accepted , European Journal of Cardio-Thoracic Surgery, 2018)