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Luxembourg Institute of Health (LIH)
Early career investigator (ECI):
Short biography of member:
My background training is in Biological Sciences, focusing on Biology and Health during my PhD in France and a post-doc in the US. I joined the Luxembourg Institute of Health (LIH) in 2005 and became Head of the Cardiovascular Research Unit in 2017. My main interest is the discovery and validation of novel RNA biomarkers and therapeutic targets of cardiac disease. Since my research is translational and I believe that collaboration can forward this area of research, I founded the Cardiolinc network in 2014 to bring together complementary expertise from clinicians, basic researchers, statisticians, bioinformaticians, systems biologists, and industrials, towards the satisfaction of unmet medical needs.
10 MAIN PUBLICATIONS Stammet P, Wagner DR, Gilson G, Devaux Y. Modeling Serum Level of S100B and Bispectral Index to Predict Outcome After Cardiac Arrest. J Am Coll Cardiol.2013; 62(9):851-858. Vausort M, Wagner DR, Devaux Y. Long Non-Coding RNAs in Patients with Acute Myocardial Infarction. Circ Res. 2014; 115(7):668-677 Goretti E, Wagner D.R., Devaux Y. miRNAs as biomarkers of myocardial infarction: a step forward towards personalized medicine? Trends Mol Med. 2014; 20(12):716-725. Stammet P, … Devaux Y, … Nielsen N and the TTM-trial investigators. Neuron specific enolase as predictor of death or poor neurological outcome after out-of hospital cardiac arrest and targeted temperature management at 33°C and 36°C. J Am Coll Cardiol. 2015;65(19): 2104-2114. Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang CP, Dorn GW, Thum T, Heymans S; Cardiolinc network. Long noncoding RNAs in cardiac development and ageing. Nat Rev Cardiol. 2015; 12(7):415-425. Devaux Y, … Nielsen N and the TTM-trial investigators. Circulating miR-124-3p Predicts Outcome After Out of Hospital Cardiac Arrest. JAMA Cardiol. 2016;1(3):305-313. Vausort M, Salgado-Somoza A, Zhang L, Leszek P, Scholz M, Teren A, Burkhardt R, Thiery J, Wagner DR, Devaux Y. MICRA: Myocardial Infarction-associated Circular RNA Predicting Left Ventricular Dysfunction. J Am Coll Cardiol. 2016; 68(11):1247-1428 Devaux Y, Creemers EE, Boon RA, Werfel S, Thum T, Engelhardt S, Dimmeler S, Squire I; Cardiolinc network. Circular RNAs in heart failure. Eur J Heart Fail. 2017 ;19(6):701-709. Gomes CPC, … Baker AH, Emanueli C, Balligand JL, Devaux Y; Cardiolinc network. The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease. Mol Ther Nucleic Acids. 2017; 8:494-507 Boileau A, Lalem T, Vausort M, Zhang L, Devaux Y; Cardiolinc network. A 3-gene panel improves the prediction of left ventricular dysfunction after acute myocardial infarction. Int J Cardiol. 2018 Mar 1;254:28-35