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The Hatter Cardiovascular Institute, University College London
Early career investigator (ECI):
Short biography of member:
Sean Davidson obtained his PhD in Melbourne, Australia on the regulation of heat shock proteins HSPs. During a postdoctoral position in Paris, he demonstrated that small HSPs are essential for early cardiac development. He moved to London in 1998 and now works at the Hatter Cardiovascular Institute at University College London, where he researches methods to protect the heart from ischaemia and reperfusion injury. A focus of his interest lies in discovering the mechanism by which transient ischaemia of the limb can induce protection in the heart – a phenomenon known as “remote ischaemic conditioning”. In the last few years he has been exploring the potential intracellular signalling role of endogenous nanoparticles called exosomes, as well as their role in cardioprotection.
He is actively involved in the scientific community of cardiovascular research, and serves on the committees of the British Society for Cardiovascular Research (BSCR) and on the European Society of Cardiology (ESC) Working Group on Cell Biology of the Heart. He is an associate editor of Cardiovascular Drugs and Therapy, and Cardiovascular Research.
GB, United Kingdom of Great Britain and Northern Ireland
Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion. Rossello X, Riquelme JA, Davidson SM, Yellon DM. J Cell Mol Med. 2017 Nov 20. doi: 10.1111/jcmm.13394
Exosomes and cardioprotection - A critical analysis. Davidson SM, Yellon DM. Mol Aspects Med. 2017 Nov 14. pii: S0098-2997(17)30141-3
Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology. Sluijter JPG, Davidson SM*[ Joint first authors], Boulanger CM, Iren Buzás E, de Kleijn DPV, Engel FB, Giricz Z, Hausenloy DJ, Kishore R, Lecour S, Leor J, Madonna R, Perrino C, Prunier F, Sahoo S, Schiffelers RM, Schulz R, Van Laake LW, Ytrehus K, Ferdinandy P. Cardiovasc Res. 2018 Jan 1;114(1):19-34
Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Hausenloy DJ, Garcia-Dorado D, Erik Bøtker H, Davidson SM, Downey J, Engel FB, Jennings R, Lecour S, Leor J, Madonna R, Ovize M, Perrino C, Prunier F, Schulz R, Sluijter JP, Van Laake LW, Vinten-Johansen J, Yellon DM, Ytrehus K, Heusch G, Ferdinandy P. Cardiovasc Res. 2017 May 1;113(6):564-585. doi: 10.1093/cvr/cvx049
Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro Davidson SM, Riquelme J, Takov K, Vicencio Bustamante JM, Boi-Doku C, Khoo V, Doreth C, Radenkovic D, Lavandero S, Yellon D J Cell Mol Med (2017) DOI:10.1111/jcmm.13302